How To Prepare PLO Gel

It is easy to prepare PLO gel.
It depends on the solubility of the medicinal agents used,
either lipophilic or hydrophilic.

For lipophilic drugs

Examples of lipophilic drugs:
Nifedipine, testosterone, amitriptyline


Stage 1

*Solubilization of drug in Organic phase

Stage 2

Addition of Aqueous phase

Stage 3

Instant formation of organogel

For hydrophilic drugs

Examples of hydrophilic drugs:
Promethazine, diclofenac, ketoprofen


Stage 1

*Solubilization of drug in Aqueous phase

Stage 2

Addition of Organic phase

Stage 3

Instant formation of organogel


* may require solvents such as propylene glycol, ethoxy diglycol & etc.