Pluronic Lecithin Organogel
Pluronic Lecithin Organogel is a transdermal system with the coexistence of organic and aqueous phase in a structurally well-defined micellar network. The organic phase, which consists of Lecithin solution, undergoes spontaneous gelation after incorporation with Pluronic aqueous solution.
Superior transdermal drug transport.
PLO gel had been demonstrated to enhance skin permeation and absorption of drugs. Being well balanced in hydrophilic and lipophilic characteristics, PLO gel can efficiently partition with the skin and enhance the transport of drug molecules into and across the skin.
Template vehicle for broader application.
PLO gel is compatible with diverse range of therapeutic agents, including lipophilic and hydrophilic drugs. Most drugs can be incorporated without stability issue. See commonly prescribed PLO gel
Ease of compounding & scale-up.
Spontaneous emulsification makes it ideal choice in pharmacy setting where time is major concern. Also, easier quality monitoring due to less chemicals and simple steps employed. Read more on how to prepare PLO gel
Biocompatible with low irritancy potential.
Use of biodegradable and nonimmunogenic materials makes PLO gel safe for long term use. The lipid enriched PLO gel also provide skin hydration so to maintain the active state of the skin.
Schematic diagram of the preparation of lecithin organogels.
Formation of a 3-dimensional network of reverse cylindrical miceller in lecithin organogels.